• Hematol. Oncol. Clin. North Am. · Feb 2018

    Review

    Pathology of Castleman Disease.

    • David Wu, Megan S Lim, and Elaine S Jaffe.
    • Department of Laboratory Medicine, University of Washington, 825 Eastlake Avenue East, Room G-7800, Seattle, WA 98109, USA. Electronic address: dwu2@uw.edu.
    • Hematol. Oncol. Clin. North Am. 2018 Feb 1; 32 (1): 37-52.

    AbstractThe term Castleman disease encompasses several distinct lymphoproliferative disorders with different underlying disease pathogenesis, and clinical outcomes. It includes unicentric and multicentric diseases with limited versus significant systemic symptoms, respectively. Importantly, the histopathologic features encountered in the various forms of Castleman disease are diverse, and for the most part, lack specificity, because they are seen to varying degrees in different clinical variants of Castleman disease, and in reactive (autoimmune/infectious) and malignant (lymphoma) contexts. Accordingly, accurate clinical diagnosis of Castleman disease requires careful and thorough clinicopathologic correlation. An overview of the key histopathologic features of Castleman disease is presented.Copyright © 2017 Elsevier Inc. All rights reserved.

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