• Frederic Blanc, Sean J Colloby, Benjamin Cretin, de SousaPaulo LoureiroPLTeam IMIS/Neurocrypto, French National Center for Scientific Research (CNRS), ICube Laboratory and Fédération de Médecine Translationnelle de Strasbourg (FMTS), University of Strasbourg, Strasbourg, France., Catherine Demuynck, John T O'Brien, Catherine Martin-Hunyadi, Ian McKeith, Nathalie Philippi, and John-Paul Taylor.
• Geriatrics day hospital and neuropsychology unit. Geriatrics department and Neurology service, Memory Resources and Research Centre (CMRR), University Hospital of Strasbourg, Strasbourg, France. f.blanc@unistra.fr.
• Alzheimers Res Ther. 2016 Jul 20; 8: 31.

BackgroundLittle is known about the patterns of brain atrophy in prodromal dementia with Lewy bodies (pro-DLB).MethodsIn this study, we used SPM8 with diffeomorphic anatomical registration through exponentiated lie algebra to measure grey matter (GM) volume and investigate patterns of GM atrophy in pro-DLB (n = 28) and prodromal Alzheimer's disease (pro-AD) (n = 27) and compared and contrasted them with those in elderly control subjects (n = 33) (P ≤ 0.05 corrected for family-wise error).ResultsPatients with pro-DLB showed diminished GM volumes of bilateral insulae and right anterior cingulate cortex compared with control subjects. Comparison of GM volume between patients with pro-AD and control subjects showed a more extensive pattern, with volume reductions in temporal (hippocampi and superior and middle gyri), parietal and frontal structures in the former. Direct comparison of prodromal groups suggested that more atrophy was evident in the parietal lobes of patients with pro-AD than patients with pro-DLB. In patients with pro-DLB, we found that visual hallucinations were associated with relative atrophy of the left cuneus.ConclusionsAtrophy in pro-DLB involves the insulae and anterior cingulate cortex, regions rich in von Economo neurons, which we speculate may contribute to the early clinical phenotype of pro-DLB.

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