• Kenei Furukawa, Tadashi Uwagawa, Taro Sakamoto, Hiroaki Shiba, Jun Tsutsumi, and Katsuhiko Yanaga.
• Department of Surgery, Jikei University School of Medicine, Tokyo, Japan k-furukawa@jikei.ac.jp.
• Anticancer Res. 2015 Jul 1; 35 (7): 4203-6.

AbstractA 68-year-old woman was diagnosed with unresectable upper bile duct cancer with suspected invasion of the right hepatic artery and para-aortic lymph node metastasis (T4N3M0, stage IVb). She underwent plastic stent placement for obstructive jaundice and enrolled in our phase I study for unresectable biliary tract cancer consisting of cisplatin (25 mg/m(2) i.v. for 120 min) followed by gemcitabine (1,000 mg/m(2) i.v. for 30 min) on days 1 and 8, and oral S-1 on alternate days. After 8 courses of neoadjuvant chemotherapy without adverse effects, computed tomography showed near-complete disappearance of the tumor of the upper bile duct and of swollen lymph nodes. She then underwent sub-total stomach-preserving pancreatico duodenectomy and lymph node dissection. The pathological stage was pT1N0M0, stage I. The patient made a satisfactory recovery, was discharged 29 days after operation, and remains free of disease at 3 months after the operation under adjuvant chemotherapy using S-1. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

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