• Laryngo- rhino- otologie · Aug 1992

    [The ototoxicity of the cytostatic drug carboplatin in patients with head-neck tumors].

    • F P Bauer, M Westhofen, and W Kehrl.
    • Hals-Nasen-Ohren-Klinik, Universitäts-Krankenhauses Eppendorf, Hamburg.
    • Laryngorhinootologie. 1992 Aug 1; 71 (8): 412-5.

    AbstractThe side effects of the anti-cancer drug carboplatin on the cochlea in 65 patients with head and neck cancer were examined in the present study. A possible dependence of ototoxicity on the patient's age, the effect of pre-existing audiometric changes and the carboplatin dose were investigated. A therapy-induced sensory hearing loss was found in 32% of the patients. The average hearing loss was 15 dB and primarily involved the frequency ranges from 4 to 8 kHz. The degree of the hearing defects incurred was not influenced by the patient's age or pre-existing hearing defects but depended on the carboplatin dose used. The severity of carboplatin cochlear ototoxicity was moderate, so that no patient suffered a lack of hearing that was of social significance.

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