• Gudula J A M Boon, Nienke van Rein, Harm Jan Bogaard, Yvonne M Ende-Verhaar, Menno V Huisman, KroftLucia J MLJMDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands., van der MeerFelix J MFJMDepartment of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands., Lilian J Meijboom, Petr Symersky, Anton Vonk Noordegraaf, and Frederikus A Klok.
• Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.
• Plos One. 2020 Jan 1; 15 (4): e0232354.

BackgroundThe pathophysiology of chronic thromboembolic pulmonary hypertension (CTEPH) is not fully understood. Poor-quality anticoagulation may contribute to a higher risk of CTEPH after acute pulmonary embolism (PE), partly explaining the transition from acute PE to CTEPH. We assessed the association between the time in therapeutic range (TTR) of vitamin-K antagonist (VKA) treatment and incidence of CTEPH after a PE diagnosis.MethodsCase-control study in which the time spent in, under and above therapeutic range was calculated in 44 PE patients who were subsequently diagnosed with CTEPH (cases). Controls comprised 150 consecutive PE patients in whom echocardiograms two years later did not show pulmonary hypertension. All patients were treated with VKA for at least 6 months after the PE diagnosis. Time in (TTR), under and above range were calculated. Mean differences between cases and controls were estimated by linear regression.ResultsMean TTR during the initial 6-month treatment period was 72% in cases versus 78% in controls (mean difference -6%, 95%CI -12 to -0.1), mainly explained by more time above the therapeutic range in the cases. Mean difference of time under range was 0% (95%CI -6 to 7) and 2% (95CI% -3 to 7) during the first 3 and 6 months, respectively. In a multivariable model, adjusted odds ratios (ORs) for CTEPH were around unity considering different thresholds for 'poor anticoagulation', i.e. TTR <50%, <60% and <70%.ConclusionSubtherapeutic initial anticoagulation was not more prevalent among PE patients diagnosed with CTEPH than in those who did not develop CTEPH.

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