• Mehmet Tetikoğlu, Serdar Aktas, Haci Murat Sağdik, Fatih Özcura, Fatma Uçar, Havva Koçak, Salim Neşelioğlu, and Özcan Erel.
• a Department of Ophthalmology , Dumlupinar University School of Medicine , Kutahya , Turkey.
• Curr. Eye Res. 2017 Jun 1; 42 (6): 876-879.

PurposeTo determine the serum thiol disulfide homeostasis in patients with pseudoexfoliation (PEX) syndrome.MethodThirty-five patients with PEX syndrome and forty healthy subjects were included in this observational case-control study. Serum native thiol, total thiol, disulfide, and native thiol/disulfide ratio were determined using a novel and automated assay.ResultsThe mean serum total thiol and native thiol levels were significantly lower in patients with PEX syndrome compared to healthy controls (p = 0.001). The mean serum disulfide level was significantly higher in patients with PEX syndrome compared to healthy controls (p = 0.023). The serum native thiol/disulfide ratio was lower in patients with PEX syndrome compared to healthy subjects (16 ± 10.1 vs 22.3 ± 11.5, respectively, p = 0.014).ConclusionOur findings provide evidence that the dynamic native thiol/disulfide ratio is lower in PEX syndrome, which shows a reduction in the natural cell reductive capacity reservoir.

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