Current eye research
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Current eye research · Jun 2017
Observational StudyThiol Disulfide Homeostasis in Pseudoexfoliation Syndrome.
To determine the serum thiol disulfide homeostasis in patients with pseudoexfoliation (PEX) syndrome. ⋯ Our findings provide evidence that the dynamic native thiol/disulfide ratio is lower in PEX syndrome, which shows a reduction in the natural cell reductive capacity reservoir.
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Current eye research · Jun 2017
Randomized Controlled TrialComparison of Autologous Serum Versus Preservative Free Artificial Tear in Patients with Dry Eyes Due to Systemic Isotretinoin Therapy.
To investigate dry eye development in the patients receiving systemic retinoic acid therapy and to compare effectiveness of Autologous Serum (AS) and preservative free artificial tear (PFAT) in the patients with dry eye disease. ⋯ AS may be an effective alternative to PFAT in the treatment of dry eye developed during isotretinoin use.
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Current eye research · Jun 2017
Expression Profile of the Integrin Receptor Subunits in the Guinea Pig Sclera.
The ocular dimensional changes in myopia reflect increased scleral remodeling, and in high myopia, loss of scleral integrity leads to biomechanical weakening and continued scleral creep. As integrins, a type of cell surface receptors, have been linked to scleral remodeling, they represent potential targets for myopia therapies. As a first step, this study aimed to characterize the integrin subunits at the messenger RNA level in the sclera of the guinea pig, a more recently added but increasingly used animal model for myopia research. ⋯ The possible contributions of integrins to scleral remodeling make them plausible targets for myopia prevention. Data from this study will help guide future ex vivo and in vitro studies directed at understanding the relationship between scleral integrins and ocular growth regulation in the guinea pig model for myopia.