• Bull. Exp. Biol. Med. · Jan 2003

    Ultralow doses of antibodies to inflammatory mediators: antitussive properties of antibodies to bradykinin, histamine, and serotonin.

    • O I Epstein, V L Kovaleva, M S Zak, and Yu L Dugina.
    • Materia Medica Holding Research-and-Production Company, Moscow.
    • Bull. Exp. Biol. Med. 2003 Jan 1; 135 Suppl 7: 146-9.

    AbstractWe studied antitussive activity of antibodies to inflammatory mediators (bradykinin, histamine, and serotonin) in ultralow doses. Experiments were performed on guinea pigs with cough induced by citric acid and capsaicin. Test preparations suppressed cough produced by citric acid. Antibodies to bradykinin in ultralow doses were most potent in relieving capsaicin-induced cough (up to 85%); antibodies to serotonin and, particularly, to histamine produced a smaller effect. Potentiated histamine and serotonin possessed polymodal properties.

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