• Larisa Stojanovič and Neža Majdič.
• Faculty of Medicine, Institute of Anatomy, University of Ljubljana, Ljubljana, Slovenia.
• J Cosmet Dermatol. 2019 Apr 1; 18 (2): 436-443.

BackgroundThe majority of aesthetic treatments today are nonsurgical or minimally invasive aesthetic procedures. Soft-tissue augmentation with hyaluronic acid (HA) is one of them. Lip fullness and definition are key aesthetic factors associated with attractiveness, which is the reason that lip augmentation with HA fillers has become so popular.ObjectiveTo provide a systematic review of published medical literature on the effectiveness and safety of different HA fillers used to enhance overall lip fullness.Methods And MaterialsThe literature search was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Twenty-two studies were included in the qualitative synthesis, 9 of them with level of evidence (LOE) 1b (randomized controlled trials), 1 with LOE 2b (individual cohort study), and 12 with LOE 4 (case series, poor-quality cohort, and case-control studies). A total number of subjects included in all studies were 3965.ResultsHyaluronic acid fillers turned out to be an effective and safe treatment. The assessment methods (especially for efficacy) varied greatly from one study to another. Observed responses to the treatment in studies using different lip fullness scales varied between 71% and 93.2%. The most common adverse events were local reactions at the injection sites (swelling, contusion, bruising, pain, redness, and itching).ConclusionBased on the results of the studies included in this systematic review, HA fillers are effective and safe to use. The majority of included subjects were satisfied with the result and their looks.© 2019 Wiley Periodicals, Inc.

19 keywords...

hide…