• Tanja Veljović, Milanko Đurić, Ivana Gušić, Jelena Mirnić, Saša Čakić, Aleksandra Maletin, and Snežana Brkić.
• 1University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; 2Department of Dentistry, Novi Sad, Serbia; 3University of Belgrade, Faculty of Dental Medicine, Department of Periodontology and Oral Medicine, Belgrade, Serbia; 4Department of Infectious Diseases, Clinical Centre of Vojvodina, Novi Sad, Serbia.
• Acta Clin Croat. 2020 Dec 1; 59 (4): 615-622.

AbstractThe 8-hydroxy-deoxyguanosine (8-OHdG) is one of the customary products of oxidized DNA. The purpose of this study was to compare salivary and plasma 8-OHdG concentrations in a group of chronic periodontitis patients to those measured in a group of patients with healthy periodontium, as well as to determine the impact of periodontal therapy on 8-OHdG concentrations in saliva and plasma in chronic periodontitis patients. The study sample comprised of 24 patients with chronic periodontitis and 16 periodontally healthy individuals. Plaque index, gingival index, papilla bleeding index, probing depth and clinical attachment level were indices used to determine patient periodontal status. Salivary and plasma 8-OHdG concentrations were determined by ELISA method. The salivary 8-OHdG concentration was statistically significantly higher in the group of periodontitis patients compared to periodontally healthy subjects. After initial periodontal therapy, the 8-OHdG concentration in saliva was significantly reduced in the periodontitis group (p=0.021). Differences in plasma 8-OHdG concentrations between the two groups did not reach statistical significance and no significant changes were noted in the periodontitis group following initial periodontal therapy. A higher salivary 8-OHdG concentration reflects increased oxidative stress caused by periodontal disease. Initial periodontal therapy may be helpful in reducing salivary 8-OHdG concentrations in chronic periodontitis patients.

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