• Acta clinica Croatica · Dec 2020

    Case Reports

    OXALIPLATIN INDUCED PULMONARY FIBROSIS: A CASE REPORT.

    • Mirjana Pavlović, Robert Šeparović, Tajana Silovski, Ana Tečić Vuger, and Andreja Jurić.
    • Sestre milosrdnice University Hospital Centre, University Hospital for Tumors, Department of Medical Oncology, Zagreb, Croatia.
    • Acta Clin Croat. 2020 Dec 1; 59 (4): 761-764.

    AbstractOxaliplatin is part of the standard chemotherapy regimens for treating colorectal carcinoma. Pulmonary fibrosis is a serious but rare side effect of oxaliplatin treatment, which resulted in patient death in more than half of the reported cases. The precise pathophysiological mechanism of this phenomenon has not been clarified yet. Analysis of the reported cases strongly suggests that early diagnosis and immediate corticosteroid treatment are crucial for better prognosis. Here we report a case of pulmonary fibrosis related to the FOLFOX regimen in a patient with early colorectal carcinoma.

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