• Baiyan Jiang, Tao Jin, Thierry Blu, and Weitian Chen.
• Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, The Republic of China.
• Magn Reson Med. 2019 Nov 1; 82 (5): 1767-1781.

PurposeCEST is commonly used to probe the effects of chemical exchange. Although R1ρ asymmetry quantification has also been described as a promising option for detecting the effects of chemical exchanges, the existing acquisition approaches are highly susceptible to B1 RF and B0 field inhomogeneities. To address this problem, we report a new R1ρ asymmetry imaging approach, AC-iTIP, which is based on the previously reported techniques of irradiation with toggling inversion preparation (iTIP) and adiabatic continuous wave constant amplitude spin-lock RF pulses (ACCSL). We also derived the optimal spin-lock RF pulse B1 amplitude that yielded the greatest R1ρ asymmetry.MethodsBloch-McConnell simulations were used to verify the analytical formula derived for the optimal spin-lock RF pulse B1 amplitude. The performance of the AC-iTIP approach was compared to that of the iTIP approach based on hard RF pulses and the R1ρ -spectrum acquired using adiabatic RF pulses with the conventional fitting method. Comparisons were performed using Bloch-McConnell simulations, phantom, and in vivo experiments at 3.0T.ResultsThe analytical prediction of the optimal B1 was validated. Compared to the other 2 approaches, the AC-iTIP approach was more robust under the influences of B1 RF and B0 field inhomogeneities. A linear relationship was observed between the measured R1ρ asymmetry and the metabolite concentration.ConclusionThe AC-iTIP approach could probe the chemical exchange effect more robustly than the existing R1ρ asymmetry acquisition approaches. Therefore, AC-iTIP is a promising technique for metabolite imaging based on the chemical exchange effect.© 2019 International Society for Magnetic Resonance in Medicine.

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