• Psychiatry research · Dec 2019

    Altered resting-state functional connectivity of the insula in individuals with clinical high-risk and patients with first-episode schizophrenia.

    • Xian-Bin Li, Lu-Bin Wang, Yan-Bing Xiong, Qi-Jing Bo, Fan He, Feng Li, Wen-Peng Hou, Yu-Jie Wen, Xue-Qi Wang, Ning-Bo Yang, Zhen Mao, Qian-Hong Dong, Fei-Fei Zhang, Rui Yang, Di Wang, Yu-Tao Xiang, Yu-Yang Zhu, Yi-Lang Tang, Zheng Yang, and Chuan-Yue Wang.
    • The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
    • Psychiatry Res. 2019 Dec 1; 282: 112608.

    ObjectivesAbnormalities in insular functional connectivity have been implicated in many clinical features of schizophrenia. The aim of this study was to determine to what degree such abnormalities occur in individuals with clinical high risk for psychosis (CHR), and whether which is associated with symptom severity.MethodsResting-state fMRI data were collected from 47 healthy controls, 24 CHR individuals and 19 patients with first-episode schizophrenia. Using the posterior, dorsal and ventral insular subregions as separate seeds, we examined resting-state functional connectivity differences between different groups and the association between concurrent symptom severity and dysconnectivity.ResultsCompared with healthy controls, both CHR individuals and schizophrenia patients showed hypoconnectivity between posterior insula (PI) and somatosensory areas, and between dorsal anterior insula (dAI) and putamen. Schizophrenia patients also showed dAI and ventral anterior insula(vAI) hyperconnectivity with visual areas relative to controls and CHR individuals. Correlation analysis revealed that dAI functional connectivity with superior temporal gyrus was positively correlated with positive symptoms of CHR, and vAI connectivity with dorsolateral prefrontal cortex was negatively correlated with the severity of the symptoms of first-episode schizophrenia.ConclusionsOur findings suggest that insular functional dysconnectivity with the sensory cortex may be a system-level neural substrate preceding the onset of psychosis.Copyright © 2019 Elsevier B.V. All rights reserved.

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