• Katharine H Polasek, Harry A Hoyen, Michael W Keith, and Dustin J Tyler.
• Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA. katharine.polasek@case.edu
• IEEE Trans Neural Syst Rehabil Eng. 2007 Mar 1; 15 (1): 76-82.

AbstractTesting of the recruitment properties and selective activation capabilities of a multi-contact spiral nerve cuff electrode was performed intraoperatively in 21 human subjects. The study was conducted in two phases. An exploratory phase with ten subjects gave a preliminary overview of the data and data collection process and a systematic phase with eleven subjects provided detailed recruitment properties. The mean stimulation threshold of 25 +/- 17 nC was not significantly different than previous studies in animal models but much lower than muscle electrodes. The selectivity, defined as the percent of total activation of the first muscle recruited before another muscle reached threshold, ranged from 27% to 97% with a mean of 55%. In each case, the muscle that was selectively activated was the first muscle to branch distal to the cuff location. This study serves as a preliminary evaluation of nerve cuff electrodes in humans prior to chronic implant in subjects with high tetraplegia.

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