• Paediatric anaesthesia · Oct 2004

    Randomized Controlled Trial Comparative Study Clinical Trial

    Caudal analgesia in children: S(+)-ketamine vs S(+)-ketamine plus clonidine.

    • M Passariello, N Almenrader, A Canneti, L Rubeo, R Haiberger, and P Pietropaoli.
    • Department of Anaesthesia and Intensive Care Medicine, Univerity of Rome La Sapienza, Rome, Italy. maurizio.passariello@libero.it
    • Paediatr Anaesth. 2004 Oct 1;14(10):851-5.

    BackgroundThe aim of this study was to evaluate postoperative analgesia provided by caudal S(+)-ketamine and S(+)-ketamine plus clonidine without local anesthetic.MethodsForty-four children aged 1-5 years consecutively scheduled for inguinal hernia repair, hydrocele repair or orchidopexy were randomly assigned to receive a caudal injection of either S(+)-ketamine 1 mg x kg(-1) (group K) or S(+)-ketamine 0.5 mg x kg(-1) plus clonidine 1 microg x kg(-1) (group KC). Postoperative analgesia and sedation were evaluated by CHEOPS and Ramsay scale from emergence from general anesthesia for 24 h.ResultsNo statistical difference was observed between study groups with respect to pain and sedation assessment. A slight trend toward a reduced requirement for rescue analgesia in group KC was observed, although not statistically significant.ConclusionsCaudal S(+)-ketamine 1 mg x kg(-1) and S(+)-ketamine 0.5 mg x kg(-1) plus clonidine 1 microg x kg(-1) are safe and provide effective postoperative analgesia in children without adverse effects.Copyright 2004 Blackwell Publishing Ltd.

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