• Funct Neurol · Jan 2000

    Review

    A pathophysiological view of primary headaches.

    • L Edvinsson.
    • Department of Internal Medicine, University Hospital, S-221 85 Lund, Sweden.
    • Funct Neurol. 2000 Jan 1; 15 Suppl 3: 50-60.

    AbstractThe cerebral circulation is innervated by sympathetic, parasympathetic and sensory nerves which store a considerable number of neurotransmitters. The role of these has been evaluated in primary headaches. A clear association between head pain and the release of calcitonin gene-related peptide (CGRP) was demonstrated. In cluster headache and in a case of chronic paroxysmal headache there was in addition release of vasoactive intestinal peptide (VIP) which was associated with facial symptoms (nasal congestion, rhinorrhea). In parallel with sumatriptan treatment head pain subsided and neuropeptide release normalised. These data show the involvement of sensory and parasympathetic mechanisms in the pathophysiology of primary headaches.

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