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Arch Argent Pediatr · Feb 2020
Case Reports[Cutaneous hyperpigmentation secondary to vitamin B12 deficiency in an infant].
- María C Viada Pelaez, María M Buján, and Andrea B Cervini.
- Servicio de Dermatología, Hospital Nacional de Pediatría "Prof. Dr. Juan P. Garrahan", Ciudad de Buenos Aires, Argentina. candeviada@hotmail.com.
- Arch Argent Pediatr. 2020 Feb 1; 118 (1): e63-e66.
AbstractCutaneous hyperpigmentation is a rare clinical feature of vitamin B12 (cobalamin) deficiency. The cause is unknown and there are different hypothesis about the pathogenesis of the hyperpigmentation. We report the case of an 8-month-old girl, with history of neuromadurative delay, hypotonia, anemia and neutropenia, who was referred to our Service by brownish hyperpigmentation on her hands and feet of 3 months of evolution. Based on the clinical suspicion of vitamin B12 deficiency, we performed a laboratory dosage that showed decreased levels of cobalamin, reason for which replacement therapy was indicated. It highlights the importance of the presumption of vitamin B12 deficiency as a cause of cutaneous hyperpigmentation and its rapid resolution after the establishment of the appropriate treatment.Sociedad Argentina de Pediatría.
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