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Arch Int Pharmacodyn Ther · Dec 1987
Digoxin-induced cardiac toxicity in the anaesthetized guinea-pigs and effect of heparin infusion.
- I Kanzik, I Cakici, A T Demiryürek, N Abacioğlu, and H Dörtlemez.
- Department of Pharmacology, Faculty of Pharmacy, Gazi University, Ankara, Turkey.
- Arch Int Pharmacodyn Ther. 1987 Dec 1; 290 (2): 165-72.
AbstractWe have examined the effects of heparin infusion on the arrhythmias induced by digoxin. Digoxin treatment consisted of 0.6 mg kg-1 given i.v. 15 min after the beginning of heparin infusion. Heparin infusions (1.7 IU, 3.4 IU and 6.8 IU kg-1 min-1) were begun 15 min before digoxin injection and continued for another 30 min. ECG, blood pressure, heart rate and arrhythmias were recorded starting 15 min before and continuing for 60 min after the digoxin injection. Heparin at the infusion rates of 3.4 IU and 6.8 IU kg-1.min-1 reduced significantly the arrhythmia scores. On the other hand, heparin did not significantly alter the arterial blood pressure and heart rate values affected by digoxin.
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