Archives internationales de pharmacodynamie et de thérapie
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Arch Int Pharmacodyn Ther · Dec 1987
Digoxin-induced cardiac toxicity in the anaesthetized guinea-pigs and effect of heparin infusion.
We have examined the effects of heparin infusion on the arrhythmias induced by digoxin. Digoxin treatment consisted of 0.6 mg kg-1 given i.v. 15 min after the beginning of heparin infusion. ⋯ Heparin at the infusion rates of 3.4 IU and 6.8 IU kg-1.min-1 reduced significantly the arrhythmia scores. On the other hand, heparin did not significantly alter the arterial blood pressure and heart rate values affected by digoxin.