• Chinese medical journal · Aug 2021

    Review

    Coronavirus disease 2019 vaccines: landscape of global studies and potential risks.

    • Hu-Da-Chuan Jiang, Yan-Yang Tao, Si-Yue Jia, Jing-Xin Li, and Feng-Cai Zhu.
    • School of Public Health, Southeast University, Nanjing, Jiangsu 210009, China.
    • Chin. Med. J. 2021 Aug 2; 134 (17): 203720442037-2044.

    AbstractWith the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, the importance of vaccines in epidemic prevention and public health has become even more obvious than ever. However, the emergence of multiple severe acute respiratory syndrome coronavirus 2 variants worldwide has raised concerns about the effectiveness of current COVID-19 vaccines. Here, we review the characteristics of COVID-19 vaccine candidates in five platforms and the latest clinical trial results of them. In addition, we further discuss future directions for the research and development of the next generation of COVID-19 vaccines. We also summarize the serious adverse events reported recently after the large-scale vaccination with the current COVID-19 vaccines, including the thromboembolism caused by the AstraZeneca and Johnson & Johnson vaccines.Copyright © 2021 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.

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