• Anila George, Zachariah Bobby, and Biswajit Dubashi.
• From the Department of Biochemistry (George, Bobby), and from the Department of Medical Oncology (Dubashi), Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
• Saudi Med J. 2021 Aug 1; 42 (8): 825-831.

ObjectivesTo assess the utility of ferritin and inflammatory biomarkers in the diagnosis of stages of breast cancer.MethodsThe study consisted of 4 groups of 20 women, including the healthy control. The patients of group 1 comprised of stages I and II, group 2: stage III and group 3: stage IV of the disease. High sensitive C-reactive protein (hsCRP) and hepcidin were estimated by enzyme linked immunosorbent assay and ferritin by chemiluminescence immunoassay. The study was carried out in 2018 at Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry-6, India.ResultsThe breast cancer disease progression correlated negatively with hemoglobin (Hb) (r= -0.6937, p<0.0001) and with ferritin levels, had a positive correlation (r=0.8444, p<0.0001). Ferritin negatively correlated with Hb among the subjects of the study (r= -0.6130, p<0.0001). Hepcidin correlated positively with hsCRP (r=0.998, p<0.0001). The ferritin/Hb ratio >3.9516 was used to identify the possibility of breast cancer utilizing the receiver operator curve values (area under curve [AUC]=0.997, sensitivity: 96.7, specificity:100). Ferritin values >103.4 were used to differentiate stage 4 from stage 3 of the disease (AUC: 0.893, sensitivity: 100, specificity: 85).ConclusionFerritin and ferritin/Hb are helpful in the differential diagnosis of stages of breast cancer.Copyright: © Saudi Medical Journal.

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