• Waleed H Mahallawi, Mohiadeen M Kurdi, and Nadir A Ibrahim.
• From the Medical Laboratory Technology Department, College of Applied Medical Sciences (Mahallawi, Ibrahim), Taibah University, and from the Hematology Laboratory Technology (Kurdi), King Fahad Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia.
• Saudi Med J. 2021 Aug 1; 42 (8): 862-868.

ObjectivesTo determine the frequency and distribution of mumps-specific IgG antibodies among the healthy adult Saudi population in Al Madinah Al Munawarah, Saudi Arabia, where mandatory vaccination against measles-mumps-rubella (MMR) has been implemented for 30 years.MethodsQualitative and quantitative indirect enzyme-linked immunosorbent assay was performed to determine the mumps IgG antibody levels in sera collected from 429 individuals, including 224 men and 205 women. Participants were stratified into 3 age groups according to vaccination history (<20, 21-30, and >31 years).ResultsThe overall seroprevalence of mumps antibodies in our population was 79.0%. The highest proportion of individuals with IgG antibody seropositivity, at 87.8% (95% confidence interval (95% CI): 84.7%-90.8%), was observed among the <20 years age group, who received 2 doses of vaccine. No significant relationships were observed between mumps seropositivity and age group or gender. The multivariable analysis identified the male gender and the age group >31 years as factors associated with an increased likelihood of seronegativity. Al Madinah Al Munawarah has achieved increased anti-mumps antibody seroprevalence since the implementation of the 2-dose MMR vaccination schedule.ConclusionsBased on our study findings, we recommend that serological screening be performed to assess the need for mumps vaccination among adults at high risk for exposure and transmission.Copyright: © Saudi Medical Journal.

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