• Ana Laura Albertoni Giraldes, Angela Maria Sousa, Alexandre Slullitel, Gabriel Magalhães Nunes Guimarães, Melina Geneviève Mary Egan Santos, Renata Evangelista Pinto, Hazem Adel Ashmawi, and Rioko Kimiko Sakata.
• Department of Anesthesia, Surgery Division, Pediatric Anesthesia Unit, Federal University of São Paulo, São Paulo, Brazil.
• J Clin Anesth. 2016 Feb 1; 28: 62-6.

Study ObjectiveThe purpose of this trial was to assess if tramadol wound infiltration is superior to intravenous (IV) tramadol after minor surgical procedures in children because tramadol seems to have local anesthetic-like effect.DesignRandomized double-blind controlled trial.SettingPostanesthesia care unit.PatientsForty children, American Society of Anesthesiologists physical status I or II, scheduled to elective inguinal hernia repair.InterventionsChildren were randomly distributed in 1 of 2 groups: IV tramadol (group 1) or subcutaneous infiltration with tramadol (group 2). At the end of the surgery, group 1 received 2 mg/kg tramadol (3 mL) by IV route and 3-mL saline into the surgical wound; group 2 received 2 mg/kg tramadol (3 mL) into the surgical wound and 3-mL saline by IV route.MeasurementsIn the postanesthesia care unit, patients were evaluated for pain intensity, nausea and vomiting, time to first rescue medication, and total rescue morphine and dipyrone consumption.Main ResultsPain scores measured during the postanesthesia recovery time were similar between groups. Time to first rescue medication was shorter, but not statistically significant in the IV group. The total dose of rescue morphine and dipyrone was also similar between groups.ConclusionsWe concluded that tramadol was effective in reducing postoperative pain in children, and there was no difference in pain intensity, nausea and vomiting, or somnolence regarding IV route or wound infiltration.Copyright © 2016 Elsevier Inc. All rights reserved.

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