• Sevda Diker, Arzu Ceylan Has, Aslı Kurne, Rahşan Göçmen, Kader Karlı Oğuz, and Rana Karabudak.
• Department of Neurology, Faculty of Medicine, Near East University, Nicosia 99138, Cyprus. Electronic address: sevdaomrumdiker@gmail.com.
• Mult Scler Relat Disord. 2016 Nov 1; 10: 14-21.

BackgroundMultiple sclerosis can impair cognition from the early stages and has been shown to be associated with gray matter damage in addition to white matter pathology.ObjectivesTo investigate the profile of cognitive impairment in clinically isolated syndrome (CIS), and the contribution of cortical inflammation, cortical and deep gray matter atrophy, and white matter lesions to cognitive decline.MethodsThirty patients with clinically isolated syndrome and twenty demographically- matched healthy controls underwent neuropsychologic assessment through the Rao Brief Repeatable Battery, and brain magnetic resonance imaging with double inversion recovery using a 3T scanner.ResultsPatients with clinically isolated syndrome performed significantly worse than healthy controls on tests that evaluated verbal memory, visuospatial learning and memory, and verbal fluency. Significant deep gray matter atrophy was found in the patients but cortical volume was not lower than the controls. Visual memory tests correlated with the volume of the hippocampus, cerebral white matter and deep gray matter structures and with cerebellar cortical atrophy. Cortical or white matter lesion load did not affect cognitive test results.ConclusionIn our patients with CIS, it was shown that cognitive impairment was mainly related to cerebral white matter, cerebellar cortical and deep gray matter atrophy, but not with cortical inflammation, at least in the early stage of disease.Copyright © 2016 Elsevier B.V. All rights reserved.

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