Multiple sclerosis and related disorders
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Mult Scler Relat Disord · Nov 2016
The association of cognitive impairment with gray matter atrophy and cortical lesion load in clinically isolated syndrome.
Multiple sclerosis can impair cognition from the early stages and has been shown to be associated with gray matter damage in addition to white matter pathology. ⋯ In our patients with CIS, it was shown that cognitive impairment was mainly related to cerebral white matter, cerebellar cortical and deep gray matter atrophy, but not with cortical inflammation, at least in the early stage of disease.