• African health sciences · Dec 2020

    Micro RNAs and the biological clock: a target for diseases associated with a loss of circadian regulation.

    • Qianwen Ma, Genlin Mo, and Yong Tan.
    • Gynecology department, Zhenjiang Hospital Affiliated to Nanjing University of Chinese Medicine (Zhenjiang Hospital of Traditional Chinese Medicine), Zhenjiang, China.
    • Afr Health Sci. 2020 Dec 1; 20 (4): 1887-1894.

    BackgroundCircadian clocks are self-sustaining oscillators that coordinate behavior and physiology over a 24 hour period, achieving time-dependent homeostasis with the external environment. The molecular clocks driving circadian rhythmic changes are based on intertwined transcriptional/translational feedback loops that combine with a range of environmental and metabolic stimuli to generate daily internal programing. Understanding how biological rhythms are generated throughout the body and the reasons for their dysregulation can provide avenues for temporally directed therapeutics.SummaryIn recent years, microRNAs have been shown to play important roles in the regulation of the circadian clock, particularly in Drosophila, but also in some small animal and human studies. This review will summarize our current understanding of the role of miRNAs during clock regulation, with a particular focus on the control of clock regulated gene expression.© 2020 Ma Q et al.

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