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Anticancer research · Jul 2001
Dacarbazine DTIC and carboplatin as an outpatient treatment for disseminated malignant melanoma.
- P Nieboer, N H Mulder, W T Van Der Graaf, P H Willemse, and G A Hospers.
- Department of Medical Oncology, University Hospital Groningen, The Netherlands.
- Anticancer Res. 2001 Jul 1; 21 (4B): 3115-6.
AbstractOccasionally long-term survival in disseminated melanoma can be obtained through chemotherapy. We treated 22 patients with disseminated melanoma with an outpatient regimen consisting of dacarbazine (DTIC) and carboplatin. Three patients had a complete response lasting 4+, 9 and 9 months (survival 4+, 10 and 16 months), respectively; 3 patients had a partial response lasting 4, 6 and 8 months (survival 6+, 11+ and 14 months), respectively. Overall response was 27% (95% confidence interval 11-50%). Toxicity was relatively mild and mainly due to nausea. In 3 patients the dose of carboplatin was reduced because of grade 4 haematological toxicity. This described easy outpatient regimen shows comparable results as other polychemotherapeutic regimens in disseminated melanoma, but with a relatively mild toxicity profile.
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