• Elise A J de Savornin Lohman, T J J de Bitter, G Hannink, M F T Wietsma, E Vink-Borger, I D Nagtegaal, T J Hugh, A J Gill, N Bhimani, M Seyed Ahadi, R S van der Post, and Philip R de Reuver.
• Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Surgery, Nijmegen, The Netherlands.
• Ann. Surg. 2023 Apr 1; 277 (4): e856e863e856-e863.

ObjectiveThe aim of this study was to develop and validate a clinical prediction model to predict overall survival in patients with nonmetastatic, resected gallbladder cancer (GBC).BackgroundAlthough several tools are available, no optimal method has been identified to assess survival in patients with resected GBC.MethodsData from a Dutch, nation-wide cohort of patients with resected GBC was used to develop a prediction model for overall survival. The model was internally validated and a cohort of Australian GBC patients who underwent resection was used for external validation. The performance of the American Joint Committee on Cancer (AJCC) staging system and the present model were compared.ResultsIn total, 446 patients were included; 380 patients in the development cohort and 66 patients in the validation cohort. In the development cohort median survival was 22 months (median follow-up 75 months). Age, T/N classification, resection margin, differentiation grade, and vascular invasion were independent predictors of survival. The externally validated C-index was 0.75 (95%CI: 0.69-0.80), implying good discriminatory capacity. The discriminative ability of the present model after internal validation was superior to the ability of the AJCC staging system (Harrell C-index 0.71, [95%CI: 0.69-0.72) vs. 0.59 (95% CI: 0.57-0.60)].ConclusionThe proposed model for the prediction of overall survival in patients with resected GBC demonstrates good discriminatory capacity, reasonable calibration and outperforms the authoritative AJCC staging system. This model can be a useful tool for physicians and patients to obtain information about survival after resection and is available from https:// gallbladderresearch.shinyapps.io/Predict_GBC_survival/.Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

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