• Zhimin Zhang, Shoushui Wei, Guohun Zhu, Feifei Liu, Yuwen Li, Xiaotong Dong, Chengyu Liu, and Feng Liu.
• School of Control Science and Engineering, Shandong University, Jinan, People's Republic of China. School of Information Technology and Electrical Engineering, University of Queensland, Queensland, Australia.
• Physiol Meas. 2018 Nov 26; 39 (11): 115005.

ObjectiveSleep quality helps to reflect on the physical and mental condition, and efficient sleep stage scoring promises considerable advantages to health care. The aim of this study is to propose a simple and efficient sleep classification method based on entropy features and a support vector machine classifier, named SC-En&SVM.ApproachEntropy features, including fuzzy measure entropy (FuzzMEn), fuzzy entropy, and sample entropy are applied for the analysis and classification of sleep stages. FuzzyMEn has been used for heart rate variability analysis since it was proposed, while this is the first time it has been used for sleep scoring. The three features are extracted from 6 376 730 s epochs from Fpz-Cz electroencephalogram (EEG), Pz-Oz EEG and horizontal electrooculogram (EOG) signals in the sleep-EDF database. The independent samples t-test shows that the entropy values have significant differences among six sleep stages. The multi-class support vector machine (SVM) with a one-against-all class approach is utilized in this specific application for the first time. We perform 10-fold cross-validation as well as leave-one-subject-out cross-validation for 61 subjects to test the effectiveness and reliability of SC-En&SVM.Main ResultsThe 10-fold cross-validation shows an effective performance with high stability of SC-En&SVM. The average accuracy and standard deviation for 2-6 states are 97.02  ±  0.58, 92.74  ±  1.32, 89.08  ±  0.90, 86.02  ±  1.06 and 83.94  ±  1.61, respectively. While for a more practical evaluation, the independent scheme is further performed, and the results show that our method achieved similar or slightly better average accuracies for 2-6 states of 94.15%, 85.06%, 80.96%, 78.68% and 75.98% compared with state-of-the-art methods. The corresponding kappa coefficients (0.81, 0.74, 0.72, 0.71, 0.67) guarantee substantial agreement of the classification.SignificanceWe propose a novel sleep stage scoring method, SC-En&SVM, with easily accessible features and a simple classification algorithm, without reducing the classification performance compared with other approaches.

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