• Yu Tian, Xiuyuan Li, Yuefu Wang, Wei Zhao, Chunrong Wang, Yuchen Gao, Sudena Wang, and Jia Liu.
• Department of Anesthesiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Department of Anesthesiology, Beijing An Zhen Hospital, Capital Medical University, Beijing, China.
• J. Cardiothorac. Vasc. Anesth. 2022 Apr 1; 36 (4): 1014-1020.

ObjectivesThe existing literature has shown conflicting results regarding the association between preoperative statin exposure and the risk of postoperative cardiac surgery-associated acute kidney injury (CSA-AKI).DesignA single-center retrospective observational study.SettingA single, large, tertiary care center.ParticipantsAdult patients undergoing open cardiac surgery between January 1, 2012 and January 1, 2019.InterventionsAKI was defined using the Kidney Disease: Improving Global Outcomes criteria. A multivariate logistic regression analysis and propensity score-matched analysis were used to study the association.Measurements And Main ResultsA total of 58,399 patient charts were retrospectively reviewed. The preoperative statin exposure cohort had a lower prevalence of all stages of CSA-AKI (30.7% v 36.3%, p < 0.001) and stage 3 CSA-AKI (0.9% v 2.1%, p < 0.001). After adjusting for confounding factors, preoperative statin exposure was a protective factor against all stages of postoperative CSA-AKI (odds ratio [OR], 0.885, 95% confidence interval [CI], 0.852-0.920, p < 0.001) and stage 3 CSA-AKI in adults (OR, 0.671, 95% CI, 0.567-0.795, p < 0.001). A propensity score-matched analysis showed that the preoperative statin exposure cohort had a lower risk of all stages of postoperative CSA-AKI (30.7% v 35.3%, p < 0.001) and stage 3 CSA-AKI (0.9% v 2.2%, p < 0.001) than the control cohort.ConclusionsPreoperative statin exposure was associated with all stages of postoperative CSA-AKI and stage 3 CSA-AKI.Copyright © 2021 Elsevier Inc. All rights reserved.

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