• Chinese medical journal · Jul 2021

    Review

    Oxidative stress in leukemia and antioxidant treatment.

    • Chao Dong, Nai-Jin Zhang, and Li-Jun Zhang.
    • Department of Hematology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China.
    • Chin. Med. J. 2021 Jul 12; 134 (16): 1897-1907.

    AbstractOxidative stress is caused by the imbalance between the generation of free radicals/reactive oxygen species (ROS) and the antioxidant defense systems, which can activate various transcription factors and affect their transcriptional pathways. Oxidative stress plays an important role in the occurrence and development of leukemia and is closely related to the treatment and prognosis of leukemia. The standard chemotherapy strategies for the pre-treatment of leukemia have many drawbacks. Hence, the usage of antioxidants and oxidants in the treatment of leukemia is being explored and has been preliminarily applied. This article reviews the research progress of oxidative stress and leukemia. In addition, the application of antioxidants treatment in leukemia has been summarized.Copyright © 2021 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.

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