• Acta Anaesthesiol Belg · Jan 1975

    Biotransformation and toxicity of local anesthetics.

    • G T Tucker.
    • Acta Anaesthesiol Belg. 1975 Jan 1; 23 Suppl: 123-40.

    AbstractThe biotransformation of clinically important ester- and amide-type local anesthetic agents is reviewed with emphasis on their fate in man. Aspects considered include: 1 degree the contribution of biotransformation to overall pharmokinetic profiles and systemic safety; 2 degrees the effect of disease on biotransformation; 3 degrees biotransformation and fate in the neonate; 4 degrees pathways and products of biotransformation; 5 degrees pharmacokinetics of metabolites; 6 degrees pharmacological activity and toxicity of metabolites.

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