Acta anaesthesiologica Belgica
-
The biotransformation of clinically important ester- and amide-type local anesthetic agents is reviewed with emphasis on their fate in man. Aspects considered include: 1 degree the contribution of biotransformation to overall pharmokinetic profiles and systemic safety; 2 degrees the effect of disease on biotransformation; 3 degrees biotransformation and fate in the neonate; 4 degrees pathways and products of biotransformation; 5 degrees pharmacokinetics of metabolites; 6 degrees pharmacological activity and toxicity of metabolites.
-
Acta Anaesthesiol Belg · Jan 1975
First experiences with a documentation system via display terminals.
A documentation and monitoring system has been developed by members of the Department of Anesthesiology and the Department of Medical Data Processing of the Rheinisch-Westfälische Technische Hochschule Aachen. It is conceived in such a way that it should cover all the needs of the department, which is to say that every anesthesia done by a staff member should be documented, supervised and assisted by the computer service. ⋯ They display both alphanumerics and graphics in four different colors and modes. Information is entered in the system via so-called masks, which contain a larger section of information, and by on-line data recording.