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Emerg Microbes Infect · Dec 2020
LetterSARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease.
- Pengfei Wang, Lihong Liu, Manoj S Nair, Michael T Yin, Yang Luo, Qian Wang, Ting Yuan, Kanako Mori, Axel Guzman Solis, Masahiro Yamashita, Ankur Garg, Lawrence J Purpura, Justin C Laracy, Jian Yu, Leemor Joshua-Tor, Joseph Sodroski, Yaoxing Huang, and David D Ho.
- Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
- Emerg Microbes Infect. 2020 Dec 1; 9 (1): 2091-2093.
AbstractWe studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ∼5-fold and ∼7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.
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