• Annals of hematology · May 2007

    Clinical Trial

    Zinc protoporphyrin, a useful parameter to address hyperferritinemia.

    • Georgia Metzgeroth, Beate Schultheis, Alexandra Dorn-Beineke, Rüdiger Hehlmann, and Jan Hastka.
    • III. Medizinische Universitätsklinik Mannheim, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Germany.
    • Ann. Hematol. 2007 May 1; 86 (5): 363-8.

    AbstractZinc protoporphyrin (ZPP) is produced instead of heme as soon as iron support to erythropoiesis becomes insufficient. In iron deficiency the intra-erythrocytic ZPP concentration is increased. The aim of this study was to investigate whether ZPP is influenced by increased iron levels in hereditary hemochromatosis (HE) and is useful in the clarification of hyperferritinemia. Twenty HE patients and 160 patients with hyperferritinemic caused by anemia of chronic disorders, liver diseases, transfusional iron overload and hematologic or solid malignancies were enrolled. ZPP was measured using the Aviv front-face hematofluorometer (normal

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