• Gete Berihun, Zebader Walle, Leykun Berhanu, and Daniel Teshome.
• Department of Environmental Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
• Patient Prefer Adher. 2021 Jan 1; 15: 179518051795-1805.

BackgroundDespite the implementation of different COVID-19 prevention measures, the incidence of the disease continues to rise. Hence, vaccines have been taken as the best option for controlling the transmission of the disease. Although the approved COVID-19 vaccines have proven to be safe and effective, multiple beliefs and misconceptions still exist influencing its acceptance.ObjectiveTo assess the acceptance of the COVID-19 vaccine and determinant factors among chronic patients visiting Dessie Comprehensive Specialized Hospital, Northeastern Ethiopia.MethodsInstitution-based cross-sectional study design was used among patients with chronic diseases visiting Dessie Comprehensive Specialized Hospital from May 1 to 20, 2021 using a consecutive sampling technique. Binary logistic regression analysis using crude odd ratio (COR) and adjusted odd ratio (AOR) was performed to assess the association between independent and dependent variables. Variables having p values of less than 0.05 at the 95% confidence interval (CI) were considered as factors of COVID-19 vaccine acceptance.ResultsA total of 416 respondents participated in the survey, with a response rate of 98.6%. About 59.4% of the respondents were willing to accept the COVID-19 vaccine. Participants who had health insurance (AOR=1.812; 95% CI: 1.703-3.059), knew anyone diagnosed with COVID-19 (AOR=2.482; 95% CI: 1.427-4.317), having good knowledge of the COVID-19 vaccine (AOR=6.890; 95% CI: 3.900-120.17), and having a positive attitude towards COVID-19 vaccine (AOR=7.725; 95% CI: 4.024-14.830) were factors affecting the acceptance of COVID-19 vaccine.ConclusionThe acceptance of the COVID-19 vaccine was low. Use of health insurance, knowing anyone who had been diagnosed with COVID-19, knowledge, and attitude towards the COVID-19 vaccine were factors of COVID-19 vaccine acceptance. Healthcare professionals should conduct continuous awareness creation campaigns on the importance of the COVID-19 vaccine, safety, and its efficacy. Further studies like longitudinal and qualitative studies should be conducted to identify additional barriers to vaccine acceptance particularly in high-risk groups.© 2021 Berihun et al.

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