• Anticancer research · Jan 2015

    Urological procedures in patients with peritoneal carcinomatosis of colorectal cancer treated with HIPEC: morbidity and survival analysis.

    • Hidde J Braam, Thijs R van Oudheusden, Ignace H J T de Hingh, Simon W Nienhuijs, Djamila Boerma, Marinus J Wiezer, and Bert van Ramshorst.
    • Department of Surgery, St. Antonius Hospital, Nieuwegein, Netherlands H.Braam@antoniusziekenhuis.nl.
    • Anticancer Res. 2015 Jan 1; 35 (1): 295-300.

    AimTo investigate whether cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS+HIPEC) is a feasible and effective option for patients with urological involvement of peritoneal carcinomatosis from colorectal cancer (CRC-PC).Patients And MethodsThe characteristics of patients with CRC-PC treated with CRS+HIPEC, with or without a urological procedure, between April 2005 and June 2013 in two tertiary Centres were analyzed.ResultsThirty-eight patients (14%) out of 267 CRC-PC patients treated with CRS+HIPEC had a urological procedure during cytoreduction. The median survival was not significantly different between patients with or without a urological procedure (26.9 versus 32.1 months, p=0.29). Severe complications occurred more in patients with a urological procedure (47% versus 20%, p<0.001). In patients with a urological procedure, the most frequent complications were gastrointestinal leakage (n=9) and intra-abdominal abscess formation (n=5).ConclusionUrological resections as a part of CRS+HIPEC in patients with peritoneal carcinomatosis of colorectal origin are feasible and effective. Severe complications are prevalent in these patients but survival is comparable to patients without involvement of the urinary system.Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

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