• Andreas A Argyriou, Ioannis Tsolakis, Spyros Papadoulas, Panagiotis Polychronopoulos, Philippos Gourzis, and Elisabeth Chroni.
• Laboratory of Clinical Neurophysiology, Department of Neurology, University of Patras Medical School, P.O. Box 1045, 26504 Rion-Patras, Greece.
• Clin Neurophysiol. 2006 Feb 1; 117 (2): 414-9.

ObjectiveThe current study aimed to assess the viability of sympathetic sudomotor fibers in patients suffering from mild peripheral arterial occlusive disease (PAD).MethodsSympathetic skin response (SSR) from the hand (electrical stimulation) and sole (electrical and magnetic stimulation) of 25 patients with PAD (19 males and 6 females with mean age 62.7 +/- 10.2 years) was recorded unilaterally depending on the side of the affected limb (18 right side, 7 left side). Electrophysiological data were also collected and correlated with the SSR results. Twenty-five, age- and gender-matched healthy volunteers served as controls.ResultsNo evidence of nerve conduction abnormalities was recorded from the group of patients. Intact SSR recordings were obtained from the upper limb of patients. Nine patients (36%) had absent SSR in the lower limb following electrical stimulation, whilst the same 9 patients had absent SSR following magnetic stimulation. Significant differences occurred between groups in the SSR latency scores recorded from the lower limb. Following electrical stimulation the mean SSR latency in patients was significantly prolonged, compared to that of controls (P = 0.000), whilst the same applied following magnetic stimulation (P = 0.000). There was no correlation between SSR abnormalities and nerve conduction measurements. The manifestation of intermittent claudication at a walking distance of 250 m was strongly correlated with absent lower limb SSR (r = 0.71, P = 0.035).ConclusionsSSR abnormalities appeared to be an early and independent finding of neural impairment in our patients.SignificanceSSR study, performed at an early stage of PAD may prove useful in differentiating PAD-induced neuropathy from other neuropathic processes.

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