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Randomized Controlled Trial Comparative Study Clinical Trial
Comparison of albumin versus bicarbonate treatment for neonatal metabolic acidosis.
- H Dixon, K Hawkins, and T Stephenson.
- Neonatal Unit, City Hospital, Nottingham, UK.
- Eur. J. Pediatr. 1999 May 1; 158 (5): 414-5.
UnlabelledIn this study the effectiveness of 4.5% human albumin was compared with 4.2% sodium bicarbonate for neonatal metabolic acidosis, using a randomised controlled trial. The change in median pH following bicarbonate was more than twice that in the albumin group. This was statistically significant.ConclusionIn normotensive infants, use of bicarbonate to correct metabolic acidosis may be more effective than use of albumin.
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