European journal of pediatrics
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Randomized Controlled Trial Comparative Study Clinical Trial
Comparison of albumin versus bicarbonate treatment for neonatal metabolic acidosis.
In this study the effectiveness of 4.5% human albumin was compared with 4.2% sodium bicarbonate for neonatal metabolic acidosis, using a randomised controlled trial. The change in median pH following bicarbonate was more than twice that in the albumin group. This was statistically significant. ⋯ In normotensive infants, use of bicarbonate to correct metabolic acidosis may be more effective than use of albumin.