• Felipe Undurraga M, Javier Vega S, Christian Fajardo J, Rodrigo Díaz G, David Lazo P, Huascar Rodríguez G, Eli Villalabeitia R, Edgardo Sepúlveda V, Jorge Rufs B, Jorge Dreyse D, Felipe Alarcón O, Josefa Valenzuela S, Natalia Seguel G, Roberto Castillo R, Lorena Arrau P, Lorena Calabrán R, Patricio Rodríguez D, and Jonathan C Yeung.
• Centro de Trasplantes, Clínica Las Condes, Santiago, Chile.
• Rev Med Chil. 2021 Feb 1; 149 (2): 171-177.

BackgroundThe number of patients waiting for a lung transplant worldwide greatly exceeds the number of available donors. Ex vivo lung perfusion is a useful tool that allows marginal donor lungs to be evaluated and reconditioned for a successful lung transplantation.AimTo describe the first Chilean and Latin American experience in ex vivo lung perfusion for marginal donor lungs before transplantation.Material And MethodsDescriptive analysis of all ex vivo lung perfusion conducted for marginal donor lungs at a private clinic, from April 2019 to October 2020. High risk donor lungs and rejected lungs from other transplantation centers were included. The "Toronto Protocol" was used for ex vivo lung perfusion. Donor lung characteristics and recipient outcomes were studied.ResultsDuring the study period, five ex vivo lung perfusions were performed. All lungs were reconditioned and transplanted. No complications were associated. There were no primary graft dysfunctions and only one chronic allograft dysfunction. There was no mortality during the first year. The median arterial oxygen partial pressure/fractional inspired oxygen ratio increased from 266 mm Hg in the donor lung to 419 after 3 hours of ex vivo lung perfusion (p = 0.043).Conclusionsex vivo lung perfusion is a safe and useful tool that allows marginal donor lungs to be reconditioned and successfully transplanted.

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