• Antoine Elyn, Nicolas Saffon, and Merlin Larson.
• Chronic Pain Unit, Neuroscience Department, University Hospital of Toulouse, Toulouse, France.
• Palliat Med. 2021 Dec 1; 35 (10): 2024-2027.

BackgroundPalliative sedation is sometimes interrupted by undesired arousals. Pupillometry has been used in anesthesiology to monitor pain and sedation but has never been used during palliative sedation.Actual CaseA 48 years-old patient, with multi-metastatic cancer, underwent palliative sedation to manage global suffering. On the second day, the patient experienced arousal which required medication adjustments to ensure pain relief and increased sedation.Possible Course Of ActionDepth of sedation is monitored with clinical scales, such as the Richmond Agitation-Sedation Scale. But these scales do not measure brain stem activity and are poor at predicting arousal.Formulation Of A PlanDuring palliative sedation, an infrared pupillometer was used to monitor pupil size and pupillary reactivity (Neurolight®, IDMed®, Marseille, France).OutcomeThe pupillary light reflex was depressed during deep sedation. In our case, we observed a low-normal reflex along with dilated pupil before arousal.Lessons From The CaseOur case suggests that reflex intensity and pupil size might predict arousals during palliative sedation.View On Research Problems, Objectives, Or Questions Generated By The CaseProspective studies are needed to confirm our findings. Pupillometry's acceptability should also be questioned from patient's, families', and caregivers' perspectives.

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