• Chiara Arienti, Lorenzo Brambilla, Silvia Campagnini, Chiara Fanciullacci, Fabrizio Giunco, Andrea Mannini, Michele Patrini, Federica Tartarone, and Maria Chiara Carrozza.
• IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
• J Res Med Sci. 2021 Jan 1; 26: 40.

BackgroundThe aim of the study was to describe the epidemiological characteristics of Nursing Homes (NHs) residents infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and to compute the related case-fatality rate.Materials And MethodsThe outcomes were mortality and case-fatality rate with related epidemiological characteristics (age, sex, comorbidity, and frailty).ResultsDuring the COVID-19 outbreak lasted from March 1 to May 7, 2020, 330 residents died in Fondazione Don Gnocchi NHs bringing the mortality rate to 27% with a dramatic increase compared to the same period of 2019, when it was 7.5%. Naso/oropharyngeal swabs resulted positive for COVID-19 in 315 (71%) of the 441of the symptomatic/exposed residents tested. The COVID-19 population was 75% female, with a 17% overall fatality rate and sex-specific fatality rates of 19% and 13% for females and males, respectively. Fifty-six percent of deaths presented SARS-CoV-2-associated pneumonia, 15% cardiovascular, and 29% miscellaneous pathologies.ConclusionPatients' complexity and frailty might influence SARS-CoV-2 infection case-fatality rate estimates. A COVID-19 register is needed to study COVID-19 frail patients' epidemiology and characteristics.Copyright: © 2021 Journal of Research in Medical Sciences.

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