• J Clin Anesth · Dec 2021

    Observational Study

    Baseline parameters for non-activated rotational thromboelastometry tests with and without heparinase in healthy pregnant women at term gestation.

    • Chloe Getrajdman, Da Wi Shin, Matthew Sison, and Daniel Katz.
    • Icahn School of Medicine at Mount Sinai, New York, NY, United States of America. Electronic address: chloe.getrajdman3@mountsinai.org.
    • J Clin Anesth. 2021 Dec 1; 75: 110484.

    ObjectiveTo determine the normal values for non-activated thromboelastometry parameters among pregnant women.DesignProspective, observational study.SettingTertiary care hospital.PatientsNon-laboring women at term gestation without history of bleeding or clotting disorder or anticoagulation use.InterventionsVenous blood samples were collected and ROTEM® was performed using NATEM and NaHEPTEM assays.MeasurementsReference ranges were derived by calculating 2.5 and 97.5 percentiles for the following parameters: clotting time (CT), clot formation time (CFT), amplitude at 10 (A10) and 20 min (A20), alpha angle, maximum clot firmness (MCF), and lysis index at 30 (LI30) and 60 min (LI60). The NATEM/NaHEPTEM CT ratio was calculated to determine the baseline ratio in term pregnant women.Main Results146 women were screened and 120 were enrolled. The median age was 34 years [31-36], median gestational age was 39.1 weeks [38.3-39.3], and median parity was 1 [0-2]. Median pre-delivery platelet and hematocrit levels were within the normal ranges. The reference ranges for NATEM parameters were: CT (232-759 (s)), CFT (69-243 (s)), alpha angle (50-77 (°)), A10 (44-69 (mm)), A20 (54-75 (mm)), MCF (57-77 (mm)), LI30 (100-100 (%)), LI60 (90-100 (%)). The reference ranges for NaHEPTEM parameters were: CT (224-717 (s)), CFT (66-210 (s)), alpha angle (53-77 (°)), A10 (44-67 (mm)), A20 (55-73 (mm)), MCF (58-74 (mm)), LI30 (99-100 (%)), LI60 (90-100 (%)). The NATEM to NaHEPTEM CT ratio reference range was 0.73-1.3.ConclusionsThis study is the first to our knowledge to report reference ranges for non-activated ROTEM® tests with and without heparinase in non-laboring term pregnant women. These reference ranges may serve as a baseline comparison and may be useful for future research on anticoagulation management in pregnancy.Copyright © 2021 Elsevier Inc. All rights reserved.

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