• Turk J Med Sci · Feb 2017

    Effects of coadministration of artemisinin and iron on histopathologicalalterations in the AGS gastric adenocarcinoma cell line.

    • Payman Zare, Amir Ali Shahbazfar, Mahsa Alem, and Salman Varmaghani.
    • Ali EBRAHIMI KATOULI, Aliasghar PARVARESH ANBAR, Pouria BAHRAMIDepartment of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
    • Turk J Med Sci. 2017 Feb 27; 47 (1): 364-367.

    Background/AimThe aim of the present study was to examine the anticancer effects of combination treatment with artemisinin and iron on the human gastric cancer cell line.Materials And MethodsThe AGS cell line was cultivated separately as a monolayer in culture flasks and different doses of 99% pure artemisinin with invariable doses of iron sulfate were added to the culture media and adhesive cells on the flask's bottom were stained with hematoxylin-eosin for a pathological assay.ResultsDamage to cancerous cells increased dose dependently and it was higher in the combination treatment groups (artemisinin plus iron). The histopathological changes were observed specially in the groups with high artemisinin concentration as cell swelling, nucleus swelling, and formation of small and large vacuolization. Necrotic changes as nucleus pyknosis were seen too. Changes in groups receiving both artemisinin and iron gradually became more severe with dose increase.ConclusionPathologic studies showed that the cytotoxic effects of artemisinin were dose dependent and the presence of iron enhanced the artemisinin's anticancer potency.

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