• J. Neurophysiol. · Jul 2005

    Comparative Study

    Calcium-stimulated adenylyl cyclases required for long-term potentiation in the anterior cingulate cortex.

    • Jason Liauw, Long-Jun Wu, and Min Zhuo.
    • Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Bldg., Rm. 3342, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.
    • J. Neurophysiol. 2005 Jul 1;94(1):878-82.

    AbstractActivity-dependent long-term potentiation (LTP) in the CNS is thought to be important in learning, memory, development, and persistent pain. Here, we report that NMDA receptor-dependent LTP is the major form of long-term plasticity in the anterior cingulate cortex (ACC). In addition to N-methyl-D-aspartate (NMDA) receptors, L-type voltage-gated calcium channels are also required for inducing LTP. Activation of calcium-stimulated adenylyl cyclase subtype 1 (AC1) is essential for the induction of LTP in ACC neurons, while AC8 subunit partially contributes to forskolin-induced potentiation. Our results suggest that calcium-stimulated cAMP-dependent signaling pathways play a critical role in cingulate LTP.

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