• Chunhong Liu, Ling Cheng, Bo Du, Shuang Cheng, Yangming Jiang, Xiaohong Tan, and Ke Qian.
• Department of Anesthesiology, People's Hospital of Chongqing Banan District.
• Medicine (Baltimore). 2021 Sep 24; 100 (38): e26695e26695.

IntroductionThe efficacy of pregabalin for pain management of shoulder arthroscopy remains controversial. We conduct this meta-analysis to explore the influence of pregabalin versus placebo on the postoperative pain intensity of shoulder arthroscopy.MethodsWe have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through November 2019 for randomized controlled trials assessing the effect of pregabalin versus placebo on pain control of shoulder arthroscopy. This meta-analysis was performed using the random-effect model.ResultsThree randomized controlled trials were included in the meta-analysis. Overall, compared with control group for shoulder arthroscopy, pregabalin remarkably decreased pain scores at 0 to 1 hour (Std. MD = -0.57; 95% CI = -1.04 to -0.09; P = .02) and 12 hours (Std. MD = -0.37; 95% CI = -0.72 to -0.02; P = .04), as well as analgesic consumption (Std. MD = -1.84; 95% CI = -2.24 to -1.44; P < .00001), but showed no notable influence on pain scores at 24 hours (Std. MD = -0.54; 95% CI = -1.47 to 0.38; P = .25), nausea or vomiting (RR = 0.84; 95% CI = 0.53-1.33; P = .45), dizziness (RR = 1.14; 95% CI = 0.89-1.47; P = .30).ConclusionsPregabalin may benefit to pain control after shoulder arthroscopy.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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