• Acta Biochim. Biophys. Sin. (Shanghai) · Mar 2021

    Review

    Cardiovascular disease in patients with COVID-19: evidence from cardiovascular pathology to treatment.

    • Jinwen Luo, Xiao Zhu, Jie Jian, Xu Chen, and Kai Yin.
    • The Department of Cardio-thoracic Surgery, Hunan Children's Hospital, Changsha 410007, China.
    • Acta Biochim. Biophys. Sin. (Shanghai). 2021 Mar 2; 53 (3): 273-282.

    AbstractThe coronavirus disease-2019 (COVID-19) caused by the novel coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has rapidly developed into a global pneumonia pandemic. Cardiovascular disease is the major comorbidity of COVID-19 patients and is closely related to the severity of COVID-19. SARS-CoV-2 infection can directly or indirectly cause a series of cardiac complications, including acute myocardial injury and myocarditis, heart failure and cardiac arrest, arrhythmia, acute myocardial infarction, cardiogenic shock, Takotsubo cardiomyopathy, and coagulation abnormalities. Intensive research on the SARS-CoV-2-associated cardiovascular complications is urgently needed to elucidate its exact mechanism and to identify potential drug targets, which will help to formulate effective prevention and treatment strategies. Hence, this review will summarize recent progress regarding the effects of COVID-19 on the cardiovascular system and describe the underlying mechanism of cardiovascular injury caused by SARS-CoV-2.© The Author(s) 2021. Published by Oxford University Press on behalf of the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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