• J. Med. Virol. · Feb 2021

    The outcome of COVID-19 in patients with hematological malignancy.

    • Tugce N Yigenoglu, Naim Ata, Fevzi Altuntas, Semih Bascı, Mehmet Sinan Dal, Serdal Korkmaz, Sinem Namdaroglu, Abdulkadir Basturk, Tuba Hacıbekiroglu, Mehmet H Dogu, İlhami Berber, Kursat Dal, Mehmet A Erkurt, Burhan Turgut, Mustafa Mahir Ulgu, Osman Celik, Ersan Imrat, and Suayip Birinci.
    • Department of Hematology and Bone Marrow Transplantation Center, Ankara Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
    • J. Med. Virol. 2021 Feb 1; 93 (2): 1099-1104.

    AbstractIn this study, we aim to report the outcomes for COVID-19 in patients with hematological malignancy in Turkey. Data from laboratory-confirmed 188 897 COVID-19 patients diagnosed between 11 March 2020 and 22 June 2020 included in the Republic of Turkey, Ministry of Health database were analyzed retrospectively. All COVID-19 patients with hematological malignancy (n = 740) were included in the study and an age, sex, and comorbidity-matched cohort of COVID-19 patients without cancer (n = 740) at a 1:1 ratio was used for comparison. Non-Hodgkin lymphoma (30.1%), myelodysplastic syndrome (19.7%), myeloproliferative neoplasm (15.7%) were the most common hematological malignancies. The rates of severe and critical disease were significantly higher in patients with hematological malignancy compared with patients without cancer (P = .001). The rates of hospital and intensive care unit (ICU) admission were higher in patients with hematological malignancy compared with the patients without cancer (P = .023, P = .001, respectively). The length of hospital stay and ICU stay was similar between groups (P = .7, P = .3, retrospectively). The rate of mechanical ventilation (MV) support was higher in patients with hematological malignancy compared with the control group (P = .001). The case fatality rate was 13.8% in patients with hematological malignancy, and it was 6.8% in the control group (P = .001). This study reveals that there is an increased risk of COVID-19-related serious events (ICU admission, MV support, or death) in patients with hematological malignancy compared with COVID-19 patients without cancer and confirms the high vulnerability of patients with hematological malignancy in the current pandemic.© 2020 Wiley Periodicals LLC.

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