• Nutr Hosp · Nov 2012

    Randomized Controlled Trial

    One-year effectiveness of two hypocaloric diets with different protein/carbohydrate ratios in weight loss and insulin resistance.

    • A Calleja Fernández, A Vidal Casariego, I Cano Rodríguez, and Ma D Ballesteros Pomar.
    • Sección de Endocrinología y Nutrición, Complejo Asistencial Universitario de León, León, España. calleja.alicia@gmail.com
    • Nutr Hosp. 2012 Nov 1; 27 (6): 2093-101.

    BackgroundThe maintenance of weight loss may be influenced by the distribution of macronutrients in the diet and insulin sensitivity.ObjectiveThe objective of the study was to evaluate the longterm effect of two hypocaloric diets with different protein/carbohydrate ratios in overweight and obese individuals either with insulin resistance (IR) or without insulin resistance (IS).DesignProspective, randomized, clinical intervention study. Forty patients were classified as IR/IS after a 75 g oral glucose tolerance test and then randomized to a diet with either 40% carbohydrate/30% protein/30% fat (diet A) or 55% carbohydrate/15% protein/30% fat (diet B).ResultsAfter one year of follow-up there was no difference in weight loss between diets A and B in each group, but the IS group maintained weight loss better than the IR group [-5.7 (3.9) vs. -0.6 (4.1); P = 0.04]. No differences were found in either Homeostasis Model Assessment (HOMA) or other metabolic glucose parameters except lower insulin at 120 minutes with diet A [21.40 (8.30) vs. 71.40 (17.11); P = 0.02].ConclusionsThe hypocaloric diets with different protein/carbohydrate ratios produced similar changes in weight. Insulin resistance may play a negative role in maintaining weight loss.

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